you could have had this entire discussion in IRC!
comma comma mad face lol
but seriously.
talking to girls is easy peasy lemon squeasy. or at least it shouldn't be as hard as some guys make it out to be. they're just people man. I was shy when I was young but at some point I realized that the anxiety or whatever is all in your mind.
talk to a girl like you'd talk to a guy.
the problem is that guys go into a conversation with a chick based on "I want to be in you" and that alters their behavior, even if subconsciously. you can't go into it like that. sure, that may very well be the goal, but if you're ever going to relax and be yourself (thus exuding confidence; the primary trait that women are attracted to) you need to just treat the approach and conversation like any other.
cold open. don't come up with lines because women can spot them.
be yourself; which sounds like the lamest and oldest advice there is but it's true. just talk. just start talking. assuming the girl you're interested in is from an environment you both share (like work, school, etc), then open with that; something you have in common even if you think it's gay. but you want to be natural, this will disarm a woman much better than if you appear like you're trying to be suave or have an agenda.
girl wants to be treated like an equal, not a conquest.
my most successful relationships have all started from total innocence. shooting the sh*t after class, gossiping about someone from work, etc.