I don't know.
I've modified the drugged view effect. The screen no longer blackens unless you're poisoned; it's clear if you're drunk. Also, when you're drugged enough for your view to start wobbling around, your gun moves counter to the wobble, making aiming nearly impossible.
What I'd like to implement are hallucinations while high on zyme. I'm trying to remember the insanity effects from Eternal Darkness. A statue that turns to face you, blood dripping down walls, the sound of someone banging on a door, seeing yourself dead in a bathtub, exploding while trying to use a spell, walking into a room and finding it upsidedown, seeing a volume display move down then back up on the screen, seeing the screen seem to turn off (thought we had a blackout for a second when that happened XD)... I think making things appear behind you for you to see when you turn around could work, and having hallucinated sounds play would also work. Maybe things could shrink as you walk away from them, or fade away as you approach, or something...