well, the 3 choices Fox gave were Moe, Skinner, and Muade. But knowing the Simpsons, there will be some crazy twist in the story where either no one dies or an insignifigant character will die. let me review the outcomes that Fox gave out:
Moe - Homer driving a Beer truck accidently drives over and kills Moe and Barney cries in front of the bar when seeing the horror.
Muade - Is at a bible camp or something like that (i forget this scenerio), and somehow (i forget this too =P) dies. Ned relies on Homer to comfort him in his time of sorrow.
Skinner - oh damn, im sorry, i forget this scenerio, but look around on the net. It will tell you.
Personally, i think there will be a real clever twist in the story, so no one might not die. But if someone does, I hope it's Muade, cos Skinner and Moe (oh, especially Moe) are the best.
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Smiley Games
"What is Mind? No Matter.
What is Matter? Never Mind"