How about pixel skipping whilst zoomed (say, Lightning Gun)? Has anyone found a way to eliminate this? With the 0.5 axis and 1.25 sens in game I have accuracy to the single pixel, but zoomed it's completely hopeless. The crosshair moves about 5 pixels at a time, and I can literally traverse the mousepad without any movement on screen if I move my hand slow enough.
I have the exact same problem in Operation Flashpoint (and higher DPI don't help either!), but in UT2004 my mouse is butter smooth.
I'm guessing it's a DirectInput issue. If you have a mouse driver but never bothered to install it, try installing it. If you have one installed, try deinstalling it and using the default. Didn't help me, but I read of people that solved their problem with this.
It has something to do with acceleration being registered wrong, I think. Not sure. In Operation Flashpoint it helped when I kept the ingame mouse sensitivity high and turned down my dpi instead to get to my desired sensitivity. At the default ingame setting the acceleration at least didn't have the cursor not moving at all and pixel skipping was less bad. But still there.
Anyway, if you do find a solution for this, be sure to post it because I would be very interested in this as well.