It could be frustration, nerves, or lack of Mountain Dew making him say this, but Midway Developer Shaun Himmerick says developing for PS3, simply put, is "a huge pain in the ass."
It may be worth noting that Himmerick was Executive Producer on upcoming UE3-powered title Wheelman.
The politically incorrect answer is that the PS3 is a huge pain in the ass. Anyone making a game, if you're going to make it for both [360 and PS3], just lead on the PS3 because if it works on the PS3 it'll work on 360.
The easiest way to look at it is, the 360 has one big chunk of memory, but the PS3 has two chunks of memory that in total are the same size as the Xbox, but because they're split you can't share memory the same way. That will bite you in the ass, and it bit us in the ass bad.
We had to play catch up on the PS3 because of the memory constraints and how it renders, how it processes is just different. And it's harder on the PS3. The Xbox is just like a dumb PC, which is great because it's easier to build a game on a PC.
It may be worth noting that Himmerick was Executive Producer on upcoming UE3-powered title Wheelman.