VG247 points out the cleverness of the Borderlands 2 writing team as is evidenced in the ESRB listing. I've got my pre-order in and I'm hoping lightning does indeed strike twice. Here's a portion:
Various weapons result in dismembered limbs or bloody gibs. Some missions depict intense acts of violence: viewing characters getting electrocuted; shooting a man in the face; killing players' incinerating a cult member as part of a ritual sacrifice. The dialogue contains jokes/one-liners that reference sexual material (e.g., "I will hang myself from my own tombstone if in you I can't put my bone," "If there's anything they love more than getting to second base with their sisters, it's cars," "Bacon is for sycophants and products of incest."); during some sequences, players can find and collect adult-themed magazines-though no actual nudity is depicted. One mission requires players to consume three alcoholic beverages from a bar before they can progress. The words "sh*t," "p*ssies," and "a*shole" can be heard in the dialogue, in addition to language censored by audible bleeps (e.g., "God-[bleep]-ing-dammit").